FOXO4-DRI for sale is a crowded search, and most of what you will find is a 10 mg vial priced anywhere from $69 to $270 with a "99%+" badge. The price tells you little. The certificate tells you a lot, and this page shows how to read it, what a fair price looks like, and when to walk away.
Key Takeaways
- FOXO4-DRI is a preclinical senolytic research peptide. There is no human evidence that it does anything, and it is not an approved drug
- On October 10, 2026 we read eight clearly priced 10 mg product pages: sale prices clustered at $11 to $14 per mg, list prices ran to $27 per mg, and one page sat at $6.90 per mg
- It is a 46-residue, all-D peptide of about 5,358 daltons, so a real COA should show a mass near that number, not just a purity percentage
- Net content matters here. One certificate we read showed 8.61 mg in a vial labelled 10 mg
- Mass spectrometry cannot tell a correct D-form from its mirror image, so ask what the lab actually tested
What FOXO4-DRI is
FOXO4-DRI is a synthetic peptide designed to interfere with the contact between the protein FOXO4 and the tumor suppressor p53 inside senescent cells, the ones that have stopped dividing but linger. The idea is that freeing p53 lets those cells die while leaving healthy ones alone. "DRI" means D-retro-inverso: the sequence is built from D-amino acids in reverse order, which makes it resistant to the enzymes that chew up normal peptides. Some sellers list it as Proxofim.
The foundational paper is Baar and colleagues, published in Cell in 2017 (PMID 28340339). Its abstract reports that the FOXO4 peptide caused selective apoptosis in senescent cells, and that in fast-aging and naturally aged mice it restored fitness, fur density and kidney function. That is a mouse and cell-culture result. Later papers are mostly reviews and more cell and animal work, and we found no published human trial. Anyone telling you what it does in a person is guessing, and this page will not guess for them.
What "FOXO4-DRI for sale" actually means
When you see FOXO4-DRI for sale, you are looking at material sold for laboratory research and labelled not for human or animal use. That label is the legal basis of the whole market, and it has plain consequences:
- No regulator checks identity, purity, sterility or fill weight before the vial ships.
- The seller alone decides which tests to run and which results to show you.
- There is no pharmacy, no prescription route and no compounding option, because the compound is not an approved drug.
- Nobody is accountable if a lot is wrong, and the seller's refund policy is the only recourse.
Legal to sell as a research chemical is not the same as approved, and neither is the same as verified. The rest of this page is about the last one.
Reading a FOXO4-DRI COA
Most guides say "make sure there is a COA" and stop. A certificate is only useful if you read the right lines. The grid below lists the six checks we would apply to any FOXO4-DRI vial.
Six checks before a FOXO4-DRI certificate counts
- 1Lot number matches
The string on the report must equal the string printed on your vial. - 2Recent analysis date
A report from a prior synthesis says nothing about this lot. - 3HPLC above 98%
Read the number and look at the chromatogram, not the badge. - 4Mass near 5,358 Da
LC-MS identity should match the expected mass for 46 residues. - 5Net content in mg
Purity is not fill: 10 mg on the label should mean close to 10 mg of peptide. - 6Endotoxin with a limit
A number alone means little unless the report states the acceptance limit.
Match the lot and the date. A product-level PDF describes a product line. A batch-specific certificate names the exact lot on your vial with a recent analysis date. If the strings differ, the document is about someone else's powder.
Read the HPLC figure and the trace. HPLC reports what share of the sample is the main peak. For a peptide this long and this unusual, a clean main peak matters more than for a short one, because truncated and deletion sequences are the typical impurities. Look for 98% or better and an actual chromatogram.
Find the mass. With 46 residues, FOXO4-DRI is about 5,358 daltons (formula C228H388N86O64, a figure that three separate product pages gave consistently). Big peptides show up in mass spectrometry as several charged peaks, so a good report shows a deconvoluted mass close to 5,358, not a vague "identity confirmed."
Ask about handedness. A mass spectrum cannot tell an all-D peptide from an all-L one of the same composition, because mirror images weigh the same. Standard HPLC on a regular column does not separate them either. We have not seen a FOXO4-DRI certificate that tests stereochemistry. It is a fair question to put to any seller, and an honest answer is "we rely on the synthesis, not on the COA."
Check net content. Purity is the share of peptide that is the right peptide. Net content is how much of the powder is peptide at all. A vial can be 99% pure and still hold far less than the label.
For a seller whose certificates read this way, Ascension Peptides publishes Kovera Labs reports covering HPLC, LC-MS identity, net content, endotoxin, sterility and heavy metals, with a public library of batch certificates. Their pass mark is above 98%, and recent batches have reported between 98.9% and 99.9%. Find the lot you would receive before you pay.
Third-party testing: independent or it does not count
In-house testing is a seller grading its own homework. Independent means the sample went to an outside lab whose report traces back to that lab. Named labs we have seen on FOXO4-DRI listings include Vanguard Laboratory, Kovera Labs and MZ Biolabs, and one page cited a lab by name without showing any result.
A familiar name on a PDF is still not proof, because a PDF can be edited. Check whether the lab publishes a way to verify the report number, and expect real traces, not a neat summary table. A listing that says "third-party tested" and shows an empty certificate image has told you nothing yet. Absence of data at the moment of purchase is usually a reliable predictor of absence of data afterwards.
Sanity-checking the FOXO4-DRI price
FOXO4-DRI is expensive to make. It is long, it is all D-amino acids, and getting a clean product takes real purification, so the market floor is higher than for short peptides. The chart below shows price per mg across the 10 mg pages we read, all checked on October 10, 2026.
Observed FOXO4-DRI price per mg, 10 mg vials, October 10, 2026
The listed prices ran from $69.00 to $270.00 for the same 10 mg. Several of the cheaper figures were sale prices against a much higher struck-through number, which tells you the "list price" is mostly decoration. Our companion guide to where to buy FOXO4-DRI compares vendors in detail; here the point is narrower. When a vial costs half of what its peers do, the saving came from somewhere, usually from testing, fill or purification. Ascension listed 10 mg at $120.00 on October 10, 2026 (regular price $199.99), and bulk tiers take 3%, 5% or 10% off at 3, 5 or 10 vials. Prices are in USD and they move, which is why the dated figure matters more than the number.
What actually arrives
A correct order is one sealed glass vial of white lyophilized powder, usually a small cake, under a crimped cap. The label should carry the compound name, quantity, lot number and a research-use statement. Diluent is sold separately and not by every seller, so check before you assume the order is complete.
Three arrival-stage warnings. A vial that arrives liquid has given up the stability that makes freeze-dried powder the standard format. A vial with a collapsed, sticky or discolored residue has met moisture or heat. And a lot number that is missing or differs from the certificate means the paperwork you checked does not apply to the product in your hand. Keep the unopened vial and the packaging until you have compared them.
Red flags: walk away
- No certificate before payment, or one that arrives only after you pay.
- A certificate with no lot number, or a lot that does not match the vial.
- A purity figure with nothing behind it: no chromatogram, no mass, no lab name.
- Net content that falls short of the label, even when purity is high.
- Prices far below the rest of the market, or permanent "50% off" banners.
- Therapeutic language: any page that suggests FOXO4-DRI treats an age-related condition, or that sells "protocols" for men or women, is selling a story the evidence does not support.
- Human-use instructions such as injection guidance written next to a "not for human consumption" notice. The seller has told you what the disclaimer is worth.
- Cryptocurrency or bank transfer only, with no card option or refund policy.
The table below shows what several of these looked like on real pages we read.
What FOXO4-DRI listings claimed versus what their own pages showed
| Listing claimed | The page actually showed | Ask the seller | |
|---|---|---|---|
| Purity | 99%+ badge | Four different figures on one page: 99.21, 99.2, 99.4 and 99+ | Which figure belongs to my lot? |
| Fill | 10 mg on the label | Certificate net content of 8.61 mg | What is the measured mg per vial? |
| Endotoxin | Endotoxin-free badge | A report line of 6.23 EU/mg with no stated limit | What limit does that number pass? |
| Identity | HPLC plus mass spec | An identity line citing only HPLC-UV against a reference | Where is the mass spectrum? |
| COA | Certificate available | An empty image placeholder where it should be | Can I read it before I pay? |
Legal and safety reality
In the US, FOXO4-DRI is not a controlled substance and is legal to sell as a research chemical. That is the extent of the comfort. It is not FDA-approved for any use, it has no human clinical record that we could find, and no regulator has examined the material you would receive. We cannot tell you it is safe, because nobody has shown that in people. Impure peptide can also provoke an immune response, which is why the paperwork above is not box-ticking.
Sellers sometimes pair the research label with ordinary retail tactics: age gates, subscriptions, countdown banners. None of that changes what the product is. If you are a researcher working with cell cultures or animal models under proper oversight, these checks protect your data. If you are thinking about personal use, speak to a physician first, and understand that no one can give you reliable dosing for a compound with no human studies.
One more practical point is storage and handling. Freeze-dried peptide is sensitive to heat and moisture, and sellers' own pages disagreed with each other here: one claimed cold-chain protection while its storage section said room temperature was usually adequate for several weeks. Treat that kind of contradiction as a signal about how carefully the rest of the page was written, and prefer a seller whose storage notes, certificate and label all say the same thing.
Pre-purchase checklist
Price is the item buyers skip, so the ladder below turns the figures above into three zones you can check in five seconds.
- The listing names the exact compound and 10 mg size, with no therapeutic claims.
- A certificate is public before purchase and its lot matches the vial you will get.
- HPLC is above 98% with a chromatogram, and the mass sits near 5,358 Da.
- Net content is reported in mg and the endotoxin line states its limit.
- The testing lab is independent and named, and the report can be verified with the lab.
- The price sits within the sale-price cluster rather than far below it.
- The seller takes cards, has a written refund policy and ships freeze-dried powder labelled for research use only.
Frequently Asked Questions
How much does FOXO4-DRI cost?
For a 10 mg vial, the pages we read on October 10, 2026 showed prices between $69 and $270, with sale prices clustering around $110 to $145 ($11 to $14.40 per mg) and list prices up to $27 per mg. Our companion vendor guide quoted a $150 to $300 range on September 27, so expect movement. Ascension listed $120.00 on the date we checked.
Is FOXO4-DRI legal to buy?
In the US it is sold openly as a research chemical and is not a controlled substance. It is not an approved drug and no pharmacy dispenses it. Rules elsewhere differ, so check your own jurisdiction before ordering.
How do I know FOXO4-DRI is real?
Appearance proves nothing, because every freeze-dried powder looks alike. Look for a batch COA whose lot matches your vial, HPLC purity above 98% with a chromatogram, a mass near 5,358 daltons, a net content in mg, and a named independent lab.
Do I need a prescription for FOXO4-DRI?
There is no prescription version to get. It is not an approved medicine in any form, and a doctor cannot lawfully prescribe it as a drug in the US, so every available supply is research material.
Does FOXO4-DRI work in humans?
Nobody knows. The published work is in cells and mice, and we found no human trial. Treat any seller who claims a human benefit as unreliable.
What is the difference between FOXO4-DRI and Proxofim?
They refer to the same compound. Proxofim is an alternative name that some listings use. Make sure the certificate names the same molecule as the listing.
Where to buy verified FOXO4-DRI
If you have decided to buy and want the certificate steps above to be easy, Ascension Peptides is the seller we point people to: batch testing by Kovera Labs covering HPLC, LC-MS identity, net content, endotoxin, sterility and heavy metals, with 85 certificates in a public library. It ships within the US only, free over $250, and all sales are final, so read the lot's certificate first. New customers get 50% off with code PEPTIDEDECK. Whoever you buy from, match the lot, read the purity, confirm the mass, and check the fill.
Medical Disclaimer: FOXO4-DRI is sold for laboratory research use only. It is not approved by the FDA or any comparable regulator for any condition and is not intended for human or veterinary consumption. The evidence described here is preclinical and no human efficacy or safety has been established. This article is educational and is not medical advice, a dosing protocol, or a recommendation for personal use. Consult a qualified healthcare professional about any health concern.
