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View allGLP-1
Semaglutide, tirzepatide, retatrutide, side effects, dosing, and access.
Peptides
Recovery, metabolism, skin health, and evidence-based peptide guides.
Drug Guides
Plain-language coverage of major GLP-1 medications and comparisons.
Diet & Side Effects
Food, protein, fiber, nausea, fatigue, reflux, and long-term routines.
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New guides from Middleway
GLP-1
Brenipatide: What It Is, Why It Is Monthly, and What Is Not Yet Known
A once-monthly GLP-1 and GIP agonist aimed at addiction and psychiatric conditions rather than obesity. The strategy is interesting. The efficacy data does not exist yet.
GLP-1
Aleniglipron (GSBR-1290): What It Is and Where the Trials Stand
Aleniglipron is an oral GLP-1 receptor agonist that is not a peptide at all. What that difference means, what phase 2 showed, and what phase 3 is testing.
GLP-1
Albiglutide (Tanzeum): What It Was and Why It Disappeared
The once-weekly GLP-1 that worked, sold for three years, and was withdrawn for commercial reasons. What it did, why it lost, and what a patient would take instead.
Peptides
AICAR Peptide Benefits: What AMPK Activation Actually Delivers
AICAR activates AMPK and produced striking endurance results in mice. Whether any of that translates to humans is a separate question, and the dose maths is the problem.
GLP-1
Adipotide (FTPP): The Fat-Targeting Peptide and Why It Never Reached People
Adipotide destroys the blood supply feeding white fat. The primate results were striking, the kidney toxicity was not, and no human trial has ever been completed.
Peptides
Bacteriostatic Water: What It Is, How to Use It and Where to Buy
Sterile water plus 0.9% benzyl alcohol, and the reason a peptide vial survives a month of needle punctures. The specification, the 28-day rule, and how to judge a supplier.
Peptides
Vilon Peptide: Dosage, the Bioregulator Idea, and What Is Documented
A two amino acid peptide from the Russian bioregulator programme, aimed at immune function and ageing. What is documented, what is hypothesis, and reported dosing.
GLP-1
Tesofensine Dosage Guide: Trial Ranges, Timing and Where the Ceiling Is
The doses studied in the phase 2 obesity work, why 1 mg was not taken forward, and the cardiovascular reason timing and dose matter more here than usual.
GLP-1
Pramlintide (Symlin): Dosage, What It Does, and Where It Fits Now
The only approved amylin analogue, dosed before every meal. Exact dosing for type 1 and type 2, what the weight loss trials actually showed, and the boxed warning.