Semax Dosage Chart: Russian Label Doses, Nasal Spray and Injection Ranges

A Semax dosage chart has to answer one question before any number: which Semax? The Russian nasal drops come in two strengths, 0.1% and 1%, and a single drop of the second carries ten times the peptide of a drop of the first. Below is the chart split by route, built from the Russian label text and published studies first, then what Reddit users say they take, then the vial math.

Our Semax peptide guide covers what Semax is and the evidence. This page covers amounts, routes and arithmetic only, and nothing here is a recommendation.

Semax dosage chart: what the Russian labels say

The only regulator-reviewed dosing for Semax is on the Russian drug labels. I read them through the RLS drug encyclopedia entry for the 0.1% solution and two medi.ru instruction pages for the 1% solution, using machine translation, so treat my wording as a reading and not a legal translation. I did not capture a registration certificate number. If you need a label for a decision, have a Russian speaker or a clinician read the current pack insert.

The figure below puts the label regimens side by side. Drops are per nostril, and the per-dose numbers are my arithmetic from the stated drop strength.

Three things in that table matter more than the headline numbers.

The two strengths are not interchangeable. The 0.1% solution contains 1 mg per mL, and the label says one drop holds 50 mcg. The 1% solution contains 10 mg per mL, and its label says one drop holds 500 mcg, with a drop volume of 0.05 mL. Those drop figures agree with the concentrations if a drop is 0.05 mL, which the 1% label states, and that is a useful check. A regimen written as "3 drops" means 150 mcg per nostril in one product and 1,500 mcg per nostril in the other.

The general-use label sits above most online charts. For the 0.1% solution the label gives 200 to 2,000 mcg per dose (3 to 30 mcg/kg) and 500 to 5,000 mcg a day, for 3 to 5 days, extendable to 14. As the RLS entry describes it, larger amounts are split into rounds of drops 10 to 15 minutes apart. Community advice of 100 to 600 mcg a day describes a different goal, no supervision and unverified product.

The big numbers belong to stroke. The 1% solution is labelled for the acute period of moderate or severe ischemic stroke, as part of complex therapy, 10 days of dosing, with a stated maximum of 20 mg a day. The matching human data is a 1997 Russian study of 30 acute stroke patients compared with 80 controls on conventional care. Its abstract says the most effective daily doses were 12 mg for moderate strokes and 18 mg for severe ones, with courses of 5 and 10 days. A 2018 Russian study of 110 post-stroke patients used a standard regimen of two 10-day courses at 6,000 mcg a day with a 20-day gap, and reported higher plasma BDNF in the Semax groups. These are hospital doses for brain injury. They are not a template for a healthy adult.

The optic nerve regimen is the most modest, a daily total of 600 to 900 mcg. The 2000 and 2001 abstracts I checked describe benefit but give no dose.

Label side effects are short. The 0.1% page lists agitation and insomnia, and the 1% pages list mild nasal mucosa irritation with prolonged use. Contraindications on the pages include hypersensitivity, acute psychotic states, anxiety disorders, pregnancy and breastfeeding, and, on the 1% pages, a history of seizures. The age cut-offs differ between pages, so I will not quote one. The anxiety disorder entry is worth noticing because Semax is often stacked with a calming peptide; see our Semax vs Selank comparison.

Nasal spray versus injection: why the number changes

Russian practice is intranasal. That is where the label, the stroke trials and the rat work all sit. The rodent paper most often cited for the nasal route reported that intranasal Semax at 50 and 250 mcg/kg raised BDNF protein in rat basal forebrain after 3 hours. That is a per-kilogram animal dose and a tissue measurement, not a human dose.

There is no approved injection product, and I found no published nasal versus subcutaneous dose comparison in people. A 2020 study in 52 healthy participants gave Semax by injection and imaged brain connectivity, but the abstract states no dose and no route comparison. Claims that injection is "drastically more powerful" or that nasal absorbs better are opinion; Reddit users hold both views.

A nasal bottle delivers a fixed volume per spray, so the dose is set by how concentrated you made the solution. A syringe lets you draw any volume, so the dose is set by how well you read a line on the barrel.

Because nobody has measured nasal versus injected exposure in people, there is no safe conversion between a label drop dose and a subcutaneous dose. Always check whether a posted "500 mcg" was sprayed, dripped or injected.

Reconstitution math and doses by vial size

Research Semax ships as lyophilized powder, commonly 5 mg or 10 mg. Dose in mcg equals concentration in mcg per mL times volume in mL; on a U-100 syringe 100 units equal 1 mL.

Worked example: add 2 mL of diluent to a 10 mg vial. The vial holds 10,000 mcg, so the concentration is 5,000 mcg per mL. A 300 mcg amount is 300 divided by 5,000, or 0.06 mL, which reads as 6 units. A 500 mcg amount is 0.10 mL, or 10 units. Add 4 mL instead and the concentration halves to 2,500 mcg per mL, so the same 300 mcg now reads 12 units. A more dilute vial is easier to read but means a larger volume.

The last row equals the strength of the Russian 0.1% solution, but that is arithmetic, not a way to make the product: the label solution contains a preservative and has manufacturing controls a hand-mixed vial lacks.

For nasal use the same math applies. A 10 mg vial made up to 5 mL total is 2,000 mcg per mL, so a spray of 0.1 mL gives 200 mcg and a 0.05 mL spray gives 100 mcg. A commenter on r/Biohacking gave this same 5 mL fill and estimated about 200 mcg a spray, which matches. The bottle's real delivered volume is the number to confirm, because everything downstream depends on it.

Reconstituted peptide does not keep indefinitely, and community guidance of a few weeks refrigerated has no Semax-specific source that I could find. A 10 mg vial at 300 mcg a day holds 33 doses, so a daily user may outlast the solution, and a 5 mg vial avoids waste. If the powder is under-filled or degraded, every figure in the table is off by the same proportion; see how to verify a Semax vial.

Semax 10 mg is sold by Ascension Peptides at $50.00 as of 2026-10-11, listed at $59.99. Kovera Labs tests every batch for HPLC purity, LC-MS identity, net content, endotoxin, sterility and heavy metals, with public batch COAs and a pass bar above 98%. They ship in the US only, sales are final, and new customers can use code PEPTIDEDECK for 50% off. It is sold as a research chemical, not for human use.

What Reddit users report

I read a Reddit export of 439 items from 20 threads across 10 subreddits. Most is noise: bots, jokes, other compounds. After discarding second-hand claims and sales pitches I found 24 usable first-hand accounts from 6 subreddits (r/BodyHackGuide 14, r/Biohacking 5, r/NooTopics 2, and one each from r/Peptidesource, r/BiohackingU and r/Biohackers). That is a small, self-selected sample, and nobody verified any claim.

Fourteen of the 24 named an amount per use. Here is how they spread.

Ten of those 14 named an amount between 300 and 500 mcg. Of the 14, 5 said they inject, 3 said they use a nasal spray and 6 did not say. One commenter reported a titration from 0.5 mg to 1.5 mg a day over about two weeks, and later said the second 1.5 mg dose felt unremarkable, so even the top of the range did not produce a steady effect for that person. Three accounts, 1,000 mcg each, include one inside a long stack with testosterone and other drugs, one that felt nothing, and one that praised cleaner focus. Those are outliers, not a safe ceiling, and a user saying a high dose caused no problem is not evidence that it is safe.

Other things the accounts describe:

• Timing of effect: A r/Biohacking commenter who injected 500 mcg wrote "I only felt the effects at day 3 and it only got better by day 8-9" (source, Aug 2026). Another, who injected 400 mcg, described focus within an hour on day one. A third said nasal effects came after a week but needed higher doses every day afterwards. Waits ranged from one hour to about ten days.
• Cycles: Reported patterns included 10 days on and 10 off, 10 on and 16 off, 4 weeks on and 4 off, and Monday to Friday dosing. None cites a source.
• Dose-finding: A r/BodyHackGuide poster who sprayed Semax found "450mcg delivered nasally is a nice, perceptible level of mental focus and concentration without being too stimmy" (source, Aug 2026), and said 600 mcg felt too stimulating. A commenter on the 1.5 mg thread replied "That is a huge dose. I take 300-500mcg and I definitely feel it" (source, Jun 2026).
• Units: Two comments gave syringe units, 6 to 12 units on a 2 mL fill (300 to 600 mcg) and 12 units a day on an unstated fill. Units mean nothing without the vial and diluent volume.

On results, 15 of the 24 accounts described some benefit, usually focus or steadier energy, and 7 said they felt little or nothing, or felt drowsy. One was unsure about placebo, and one high-dose stack was too confounded to score. Downsides were few and mild: insomnia and irritability after 400 mcg injected, nasal dryness, feeling jumpy at 600 mcg, and one person feeling "off" for two days after stopping. One commenter claimed Semax causes hair loss, citing forum chatter; I found no first-hand report in this file and no label or study that mentions it, so it is unverified.

Timing, cycle length and what changes the dose

Cycle length has no basis outside the label courses: 3 to 14 days for general use, 7 to 10 for optic nerve disease and 10 for stroke, with the 2018 study repeating a 10-day course after a 20-day gap. Longer forum cycles are practice, not protocol.

Time of day is anecdotal. Reddit accounts overwhelmingly describe a morning dose, and the label lists insomnia, a plausible reason to avoid bedtime.

The numbers from this page fit on one card.

What actually moves the dose:

1. Product and strength. 0.1% drops, 1% drops, a research vial and modified forms such as N-acetyl Semax are different products, and no regulator has published doses for the modified forms.
2. Route. Nasal, drop or injection, with no tested equivalence.
3. Body size. The 0.1% label also states its range per kilogram (3 to 30 mcg/kg per dose).
4. Goal and supervision. Stroke regimens run in milligrams under hospital care; memory and focus use is in the hundreds of micrograms.
5. Tolerance. Some users report fading effects and raise the dose, the usual route to the outlier numbers above.

For reported effects, see our Semax side effects page.

Legal status and where Semax comes from

Semax is on the Russian label pages above as a medicine. In the US there is no FDA-approved Semax product, so there is no US prescribing label and no approved dose. It has appeared on FDA's list of bulk substances considered for pharmacy compounding, and its position there changed during 2026. I could not confirm the outcome of the FDA advisory meeting, so check FDA's current list before assuming a pharmacy can supply it. In practice Semax is sold as a research chemical, not for human consumption.

Read the lot number on the COA against your vial before you reconstitute, and do your own arithmetic, because the numbers apply only to the vial you hold. Ascension's 10 mg Semax is $50.00 as of 2026-10-11, with the testing described above.

Frequently Asked Questions

What is the standard Semax dosage?

There is no single standard. The Russian 0.1% drops list 200 to 2,000 mcg per dose and 500 to 5,000 mcg a day for general use, 3 to 5 days, extendable to 14. The 1% drops are for acute stroke at 2,000 to 4,000 mcg per dose. Community charts for focus are lower, about 300 to 500 mcg.

How many mcg are in one drop of Semax?

On the Russian labels, one drop of the 0.1% solution holds 50 mcg, and one drop of the 1% solution holds 500 mcg. A drop is 0.05 mL. Check the strength printed on the bottle first, since the two are ten times apart.

What is the Semax dosage for injection?

No label or trial gives one. Reddit users who inject mostly name 300 to 500 mcg. That is an anecdote from an unverified sample, not a dose recommendation, and injection amounts have not been tested against nasal ones.

How do I calculate Semax units on a syringe?

Divide the dose in mcg by the concentration in mcg per mL, then multiply by 100 for U-100 units. A 10 mg vial with 2 mL added is 5,000 mcg per mL, so 300 mcg is 6 units.

How long do you take Semax before a break?

The Russian label courses run 3 to 14 days for general use, 7 to 10 for optic nerve disease and 10 for stroke. Reddit users report 10 days on and 10 off, 10 on and 16 off, or 4 weeks on and 4 off. None of those is tested.

Is Semax FDA approved?

No. It is approved and used in Russia. In the US it is sold only as a research chemical, and its compounding status has been under FDA review in 2026.