This sermorelin dosage chart keeps three sources apart that most dosing pages blend: the old FDA-approved Geref label, the doses used in published trials, and the amounts people on Reddit say they inject. They differ a lot, and the gaps are the useful part. Everything below is a summary of published and reported ranges, not a prescription and not medical advice.
Key Takeaways
- The only labelled sermorelin doses were for children: 30 mcg per kg under the skin at bedtime for growth failure, and a single 1 mcg per kg intravenous dose as a pituitary test. No adult anti-aging dose was ever on an FDA label
- Trials in older adults used far more than clinics do today: 2,000 mcg nightly for 6 weeks in one study, and 500 or 1,000 mcg twice daily in another
- In the Reddit data, 12 accounts gave a usable per-injection dose. 500 mcg (4 accounts) and 100 mcg (3) were the most common, almost always at night
- Geref was discontinued in 2008 for business reasons, not safety. Sermorelin today comes from compounding pharmacies on prescription, or from research-chemical vials
- Vial math is where mistakes happen: a 5 mg vial in 2 mL is 2,500 mcg/mL, so 300 mcg is 0.12 mL, or 12 units on a U-100 syringe
For what sermorelin is and how it works overall, see our sermorelin peptide guide. This page is the dose-focused companion.
Sermorelin dosage chart: label, trial and Reddit doses side by side
Start with the table, because the three columns answer different questions. The first is what a regulator once approved. The second is what researchers gave volunteers. The third is anecdote from an unverified, self-selected sample.
Sermorelin doses: label, trials and Reddit reports
| FDA label era (children) | Adult trials (older men) | Reddit reports (12 accounts) | |
|---|---|---|---|
| Amount per injection | 30 mcg/kg under the skin at bedtime; diagnostic: 1 mcg/kg intravenous, once | 500 or 1,000 mcg twice daily; 2,000 mcg nightly | 100 to 600 mcg; 500 mcg most common (4), then 100 mcg (3) |
| Schedule | Once daily; diagnostic test is a single dose | Twice daily for 14 days; nightly for 6 weeks | Mostly nightly; one 5-on, 2-off; one 10 nights a month |
| Who | Prepubertal children with idiopathic GH deficiency (Geref, withdrawn 2009) | Healthy men aged 64 to 76, 10 or 11 per study | Self-selected adults, unverified |
| What was seen | Growth in some children; flushing and injection-site pain most common | 1 mg twice daily raised GH and IGF-I; 2 mg nightly raised GH but not IGF-I | Sleep most often cited; 10 of 38 accounts reported a problem |
The Reddit column is a flat 100 to 600 mcg, taken at night. For an adult, the pediatric label figure is easy to turn into arithmetic: 30 mcg per kg for a 70 kg person would be 2,100 mcg. That is only arithmetic. The label was for children with a diagnosed deficiency, and I am not suggesting anyone scale it up.
I did not find a controlled trial of the 200 to 500 mcg nightly range that clinics and forums treat as standard, so that number rests on clinical habit. The common claim that 200 to 300 mcg is the labelled dose does not match the sources I could check.
What the FDA label and regulatory record say
I verified the regulatory facts in the Federal Register rather than from vendor pages. Sermorelin was sold in the United States as Geref, made by EMD Serono, under two applications. The 0.05 mg ampule was approved on December 28, 1990 to evaluate whether the pituitary can still secrete growth hormone. The 0.5 mg and 1 mg vials were approved on September 26, 1997 for idiopathic growth hormone deficiency in children with growth failure.
The company told FDA it was discontinuing the ampule in July 2008 and the vials in December 2008, and approval of both applications was withdrawn effective June 18, 2009. In a March 4, 2013 notice, FDA determined that neither product was withdrawn for reasons of safety or effectiveness. A DailyMed search on 2026-10-11 returned no sermorelin label.
Because there is no current label to read, I took the labelled doses from a peer-reviewed review of the drug (Prakash and Goa, BioDrugs 1999, PMID 18031173). It describes a single intravenous 1 mcg per kg dose as a diagnostic test, and once-daily subcutaneous 30 mcg per kg at bedtime as effective in some prepubertal children. It reports transient facial flushing and injection-site pain as the most common adverse events. I did not read the original US package insert, so treat the exact label wording as unverified.
There is no approved adult regimen to anchor to. Adult use today is off label, usually through a compounded product that FDA has not approved as a finished drug. Sermorelin does not appear on FDA's Category 2 list of bulk substances with safety concerns; I did not verify its Category 1 status.
What the published adult trials gave
Three small studies show how far the research doses sit from the forum doses. The first is Corpas and colleagues (JCEM 1992, PMID 1379256). Ten healthy men with a mean age of 68 took GHRH 1-29 under the skin twice daily for 14 days, at 0.5 mg and again at 1 mg, in random order. Only the 1 mg dose raised 24-hour growth hormone and IGF-I significantly, to levels not different from young men.
The second is Vittone and colleagues (Metabolism 1997, PMID 9005976). Eleven healthy men aged 64 to 76 injected 2 mg nightly for 6 weeks. Nighttime growth hormone release rose, but IGF-I did not change, body composition measured by DEXA did not change, and the authors reported no significant adverse effects. Two of six strength measures improved, and the authors concluded single nightly doses look less effective than several a day.
The third is Khorram and colleagues (JCEM 1997, PMID 9141536), and it comes with a warning: the drug was a modified analog, [Nle27]GHRH-(1-29)-NH2, not sermorelin itself, so do not copy its numbers. It gave 19 adults aged 55 to 71 a dose of 10 mcg per kg nightly for 16 weeks. IGF-I rose within 2 weeks and drifted back toward baseline by 16 weeks, and lean mass rose in men only. Some dosing pages blend this analog with sermorelin.
Put together: the highest trial doses (1,000 to 2,000 mcg per injection) are 2 to 10 times the 200 to 500 mcg that clinics usually prescribe, and even at 2 mg nightly one study saw no IGF-I change.
Reconstitution math: mcg, mL and units
Sermorelin comes as a freeze-dried powder mixed with bacteriostatic water, and the water volume sets the concentration. The formula is dose in mcg divided by concentration in mcg per mL gives mL, and mL times 100 gives units on a U-100 insulin syringe.
Sermorelin units on a U-100 syringe by vial and water volume
| Concentration | 200 mcg | 300 mcg | 500 mcg | |
|---|---|---|---|---|
| 2 mg + 2 mL | 1,000 mcg/mL | 0.20 mL = 20 units | 0.30 mL = 30 units | 0.50 mL = 50 units |
| 5 mg + 1 mL | 5,000 mcg/mL | 0.04 mL = 4 units | 0.06 mL = 6 units | 0.10 mL = 10 units |
| 5 mg + 2 mL | 2,500 mcg/mL | 0.08 mL = 8 units | 0.12 mL = 12 units | 0.20 mL = 20 units |
| 10 mg + 2 mL | 5,000 mcg/mL | 0.04 mL = 4 units | 0.06 mL = 6 units | 0.10 mL = 10 units |
Worked example: a 5 mg vial is 5,000 mcg. Add 2 mL of water and you get 2,500 mcg/mL. A 300 mcg dose is 300 divided by 2,500, which is 0.12 mL, or 12 units. The same vial holds about 16 doses of 300 mcg. If you instead add 1 mL, the concentration doubles to 5,000 mcg/mL and the same 300 mcg is only 6 units, which is easy to get wrong when you switch between vials.
Two Reddit comments match this math: 10 units from a 5 mg vial in 1 mL for 500 mcg, and 0.1 mL per 100 mcg from a 2 mg vial in 2 mL. A third said the prescribed dose was 33 units from a vial described as 0.9 mg in 10 mL, which works out to roughly 30 mcg if taken literally, so something was misreported. Compare doses in micrograms, not units, because a unit means nothing without the concentration.
If you hold a 10 mg research vial, the same method applies: 2 mL of water gives 5,000 mcg/mL and a 300 mcg dose of 6 units. Ascension Peptides lists Sermorelin 10 mg at $72.00 on 2026-10-11 (regular price shown as $99.99), with per-batch Kovera Labs testing and public batch certificates. US shipping only, all sales are final, and the research designation means it is not sold for human use.
Timing, frequency and cycle length
Nearly everything reported is a bedtime injection. In the Reddit data, 9 first-hand accounts said nightly or at bedtime, one said 5 days on and 2 days off, one said 10 nights a month, and one injects in the morning alongside two other peptides because nighttime use gave very vivid dreams. The rationale is to amplify the nighttime growth hormone pulse, and several leave a couple of hours after eating. No trial I found compared timing or meal gaps.
Cycle length is mostly habit. Commenters mention a planned 6-month course, a 3-month prescribed course, 8 weeks on and 2 off, 6 weeks, and one person who used it nearly every day for a year. These are routines, not evidence. The trials above ran 14 days to 16 weeks.
On when anything shows up, the accounts disagree. One person felt less winded within 2 days, another reported better sleep after 2 days, one after about 3 weeks, and one wrote that effects came late and quietly: "Probably nothing for 90 days, then at 6 months you're in a rhythm." (a r/Sermorelin commenter, Jan 2024). Another saw nothing at 2.5 months.
What Reddit users report taking
I read 407 scraped items and kept the first-hand ones: 38 comments and posts from 5 subreddits across 6 threads, mostly r/Sermorelin (31). Of those, 20 gave some dose figure and 12 gave a clear per-injection amount in mcg. That is a small, self-selected sample of people who chose to post, so read it as anecdote. Vendor pitches, price-shopping, bots and other compounds were dropped.
Per-injection sermorelin amounts Reddit users named
The most common current amounts were 500 mcg (4 accounts, one of them a sublingual tablet) and 100 mcg (3). The middle of the 12 is about 350 mcg. Ramping was common: several started at 100 to 250 mcg and moved up to 300 to 600 mcg over weeks. One commenter said anything over 200 mcg is wasted, which is an opinion, not data.
Four more accounts gave only a volume from a prescribed vial (0.1 cc, 0.2 mL, 0.3 mL and 0.33 mL), which cannot be converted without the vial strength. Three posts were unclear or implausible: one equated 10 units with 3 mg, one gave 15 mg in 0.5 mL, and one wrote a dose of 0.9 mcg a day with a hedge. I treat those as errors or confusion, not as doses. Another commenter asked whether 2 mg nightly would be fine with slow titration, having read that some people go that high; that is a number from forums, not from a clinician.
What people said happened is mixed. Of the 38, 7 reported better sleep, 5 more energy, endurance or less brain fog, 5 better muscle tone or recovery, and 5 little, late, or faded effect. Ten reported something unwanted: sore, itchy red welts at the injection site (2), vivid dreams (2), insomnia or worse sleep (2), swelling or pain in the hands and feet (1), allergic sensitivity that ended use (1), and a first dose of 200 mcg that brought a hot flash and fatigue (1):
"My initial dose was 200mcg, and I immediately got a hot flash that last about an hour along with EXTREME fatigue" (a r/Sermorelin commenter, Sep 2023).
The dreams complaint came with a workaround: "Taking it at night gives me craaazzzyyyy dreams" (a r/Sermorelin commenter, May 2026), said by a user who moved the injection to morning. One commenter described an emergency room visit with vomiting and said a doctor attributed it to antibodies; that is a single secondhand account and I could not verify it. Our sermorelin side effects page covers documented adverse events in more depth, and does sermorelin work covers the evidence for the effects people describe.
What changes the dose
These are the variables that appear in sources, none of which can be turned into a personal number here.
Age and baseline IGF-I. A GHRH signal only helps if the pituitary can answer. Clinicians check IGF-I before and during treatment, which is why a prescriber, not a chart, should pick the number.
Dose and frequency. Corpas suggests larger or more frequent doses move hormone levels more, and Vittone found 2 mg once a night did not change IGF-I in older men.
Product form. Injection is the studied route. The tablet in the Reddit data (500 mcg sublingual) has no trial behind it that I found, and the user who tried it said six weeks produced no big difference. Sublingual and nasal products have no verified dose equivalence to injection.
Stacking. Some users add ipamorelin or CJC-1295. That removes any link to a sermorelin-only number. For comparisons, see CJC-1295 vs sermorelin and sermorelin vs tesamorelin, where tesamorelin is dosed in milligrams, not micrograms.
Vial age and storage. One commenter called sermorelin more fragile than some peptides past its beyond-use date. Stale or warm product would make any dose meaningless. Prices vary by program; see sermorelin cost, prescription and insurance coverage.
Where sermorelin is legally obtained
In the United States the lawful route is a prescription from a licensed clinician, filled by a compounding pharmacy, since there is no commercial FDA-approved product. Research-chemical vials are labelled not for human use, and buyers carry the identity and purity risk. Our where to buy sermorelin page covers sourcing. I did not verify any individual telehealth provider.
Frequently Asked Questions
What is the sermorelin dosage?
There is no single dosage. The old FDA label used 30 mcg per kg at bedtime for children and 1 mcg per kg intravenously as a test. Adult studies used 500 to 2,000 mcg per injection, and Reddit users most often report 100 to 500 mcg at night. Only a prescriber can set a dose for you.
What is a typical sermorelin dose for adults?
Clinic and forum routines cluster around 200 to 500 mcg nightly, but that range is not from an FDA label. Among 12 Reddit accounts, the middle was about 350 mcg, with 500 mcg the most common single amount.
How many units of sermorelin is 300 mcg?
It depends on the concentration. With a 5 mg vial in 2 mL (2,500 mcg/mL), 300 mcg is 0.12 mL, or 12 units on a U-100 syringe. With a 5 mg vial in 1 mL it is 6 units. Divide the dose by the concentration, then multiply by 100.
Should sermorelin be taken at night?
Almost all reported protocols inject at bedtime, often a couple of hours after eating, to line up with the night growth hormone pulse. One Reddit user moved to mornings to avoid vivid dreams. I found no trial comparing times of day.
Is sermorelin FDA-approved?
Not today. Geref was approved in 1990 and 1997, then discontinued in 2008 and withdrawn in 2009. FDA found in 2013 that this was not for safety or effectiveness reasons. It is now made by compounding pharmacies on prescription, or sold as a research chemical.
How long do people take sermorelin?
Reported courses range from 6 weeks to a year, with 3 to 6 months common. No study defines a correct cycle length for adults.
Checking a vial before you do any math
The calculations above assume the label is true, so confirm lot, purity and mass first. If you are working with a research vial, Ascension Peptides lists Sermorelin 10 mg at $72.00 as of 2026-10-11. Kovera Labs tests every batch (HPLC, LC-MS identity, net content, endotoxin, sterility, heavy metals) with over 98% passing, and batch certificates are public. First-time customers can use code PEPTIDEDECK for 50% off. Shipping is US only and all sales are final.
Medical disclaimer: This page is for education only and is not medical advice. Sermorelin is not currently an FDA-approved product. Dose figures are published or self-reported ranges, not recommendations or instructions. Talk to a licensed clinician before using any injectable hormone-releasing peptide.
